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   - Frozen Embryo Transfer -        Embryo Cryopreservation
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Reproductive Immunology

Blood tests may be indicated to help evaluate your prior reproductive loss or failed IVF cycles. The field of Reproductive Immunology is a relatively new area of medicine used to identify specific factors contributing to your inability to conceive/carry a pregnancy and offer medical therapy to improve your chances of delivering a child. The following tests to help you conceive and carry a pregnancy are available through the Follas IVF Center:

Autoimmune Antibodies: These antibodies may cause abnormal blood clotting, which can prevent good maternal-fetal circulation necessary for fetal growth. Low positives are often treated with baby aspirin; higher levels may require anticoagulation with Lovenox, an injectable blood thinner.

Natural Killer Cells: Normally NKC’s are made by our bodies to prevent or treat diseases such as infections and cancer. High levels of natural killer cells may interfere with normal pregnancy progression if the body abnormally detects the pregnancy as foreign. In the past, most patients with this abnormality required treatment with IVIG, which was expensive and time consuming. At the Follas center, newer protocols have evolved into using inexpensive oral medication to reduce the abnormal natural killer cell population for those patients who have suffered reproductive loss due to NKC’s.

Embryo Toxic Factor: Our white blood cells normally secrete this substance, which can accumulate due to previous miscarriages, resulting in a higher chance to lose the next pregnancy. Treatment is designed to suppress the patient’s abnormal immune response toward the developing fetus.

Results: Dr. McLaughlin compared all his patients who had an embryo transfer in 2001 (without immune testing/treatment) with those who were diagnosed and treated in 2002.

2001
Clinical Pregnancy Rate37/7649%
Miscarriage Rate7/3719%
Delivery Rate30/7639%
2002
Clinical Pregnancy Rate54/9756%
Miscarriage Rate4/547%
Delivery Rate50/9752%
He concluded that immunologic testing and treatment could help embryo implantation and pregnancy continuation in those patients undergoing ART procedures. For more information:
www.repromedix.com
FOLLAS CENTER for Reproductive Medicine, L.L.C. Noblesville, IN. 46060317-774-1212 (tel) 317-774-1212 (fax)
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